Dna strand. (n.d.). Retrieved April 25, 2017, from https://www.google.com/search?q=Dna+strand&source=lnms&tbm=isch&sa=X&ved=0ahUKEwib6YuE8sDTAhUFKiYKHTXiAokQ_AUICigB&biw=1366&bih=662#tbm=isch&q=Dna strand blue and white&imgrc=ivTwHidwU4wPFM:
Scientists have identified 2 types of genes that cause Alzheimer's Disease:
Genetic Testing- While genetic tests are available for both APOE-e4 and rare genes that directly cause Alzheimer’s, health professionals do not recommend routine genetic testing.
Genes that cause or increase the risk of developing Alzheimer’s Disease:
Amyloid precursor protein (APP) is the first gene that’s mutations cause Alzheimer’s Disease. It was discovered in 1987.
Presenilin-1 (PS-1) is the scoend gene whose mutations cause early onset Alzheimer’s Disease. The mutations almost always only cause early onset Alzheimer’s. It was discovered in 1992.
Presenilin-2 (PS-2) is the third gene whose mutations are known to cause early onset Alzheimer’s Disease. It was discovered in 1993.
Apolipoprotein E-e4 (APOE4) is the first gene found to increase the risk of developing Alzheimer’s Disease. It is the gene with the greatest impact. Having the mutation does not guarantee that the individual will develop Alzheimer’s. It was discovered in 1993.
Alzheimer's Association. (n.d.). Risk Factors. Retrieved from http://www.alz.org/alzheimers_disease_causes_risk_factors.asp
- Risk Genes- A mutation in this type of gene increases the chances of that individual developing the disease in his/her lifetime. This does not guarantee that the individual will develop the disease. apolipoprotein E-e4, or APOE-e4 is the first and the gene with the strongest impact of developing Alzheimer’s Disease.
- Deterministic Genes- directly cause the disease. If the individual has this type of gene, they will definitely develop the disease. When Alzheimer’s is caused by these genes, it is called “autosomal dominant Alzheimer’s Disease (ADAD)”. Many family members are affected and experience their first symptoms in their 50’s and 60’s. True ADAD accounts for 1 percent of cases of Alzheimer’s. Mutations in genes that make the proteins amyloid precursor protein (APP), presenilin-1 (PS-1) and presenilin-2 (PS-2) have been discovered to develop Alzheimer’s Disease.
Genetic Testing- While genetic tests are available for both APOE-e4 and rare genes that directly cause Alzheimer’s, health professionals do not recommend routine genetic testing.
Genes that cause or increase the risk of developing Alzheimer’s Disease:
Amyloid precursor protein (APP) is the first gene that’s mutations cause Alzheimer’s Disease. It was discovered in 1987.
Presenilin-1 (PS-1) is the scoend gene whose mutations cause early onset Alzheimer’s Disease. The mutations almost always only cause early onset Alzheimer’s. It was discovered in 1992.
Presenilin-2 (PS-2) is the third gene whose mutations are known to cause early onset Alzheimer’s Disease. It was discovered in 1993.
Apolipoprotein E-e4 (APOE4) is the first gene found to increase the risk of developing Alzheimer’s Disease. It is the gene with the greatest impact. Having the mutation does not guarantee that the individual will develop Alzheimer’s. It was discovered in 1993.
Alzheimer's Association. (n.d.). Risk Factors. Retrieved from http://www.alz.org/alzheimers_disease_causes_risk_factors.asp